The mission of the Institute for Cancer Genetics (ICG) is to elucidate the pathogenesis of human cancer as a means to identify novel mechanistically-based diagnostic and therapeutic approaches. Our research includes the study of general mechanisms involved in tumorigenesis (for example, DNA replication and repair, metabolism, metastasis, immune surveillance), as well as the dissection of genetic lesions underlying specific cancer types, such as leukemias and lymphomas, brain tumors, and pancreatic, breast and lung carcinomas. Structural and functional genomics, systems biology, and mouse modeling are integrated toward the identification of pre-clinical models eventually leading to collaborative clinical trials. ICG members have academic appointments with various departments at the Columbia University Irving Medical Center and are members of the Herbert Irving Comprehensive Cancer Center.