Christine Chio, PhD

Assistant Professor of Genetics & Development

Christine Chio studies Pancreatic ductal adenocarcinoma (PDAC) that represents the third leading cause of cancer death in the United States. Lethality of PDA owes largely to the advanced disease stage at the time of diagnosis and to its profound resistance to existing therapies. Targeted therapy is a cornerstone of precision medicine, and is currently the focus of much anticancer drug development. However, in the context of pancreatic cancer, no chemical inhibitors exist for the most common KRAS mutations (G12D, G12V) even though it is well established that the oncogenic KRAS promotes drug resistance. Thus, a detailed understanding of the role of specific genetic lesions and their signaling surrogates in the initiation and progression of PDA is critical to improving treatment efficacy and patient outcome for this disease. Using genetically engineered mouse models and ex vivo culture systems, the Chio lab seeks to understand the basic mechanisms underlying PDAC biology such that vulnerabilities can be identified and tested for therapeutic intervention.


Meet The Team

Christine Chio, PhD

Assistant Professor of Genetics & Development

Ipsita Pal, PhD

Postdoctoral Fellow

Marina Ayres Pereira, PhD

Postdoctoral Fellow

Jordan Lu

Undergraduate project student

Michael B. Mendelsohn

Graduate Student

Selected Publications

No publications found.

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