Laura Pasqualucci, MD

Professor of Pathology & Cell Biology

Laura Pasqualucci’s research interests are to elucidate the genetic basis of mature B cell malignancies, with emphasis on diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL). She takes advantage of integrated multi-omics approaches, biochemical assays and genetically-engineered mouse models to identify and functionally characterize human lymphoma-associated genetic alterations, understand the role of the affected genes in the physiologic germinal center (GC) reaction, a specialized microenvironment from which most B cell lymphomas come from, and dissect the mechanisms by which their dysregulation promotes lymphoma initiation and maintenance, the ultimate goal being to exploit this information for the development of novel biomarkers and rational therapeutic approaches. A major area of investigation focuses on the methyltransferase KMT2D and the acetyltransferase CREBBP, two histone/chromatin modifiers that we discovered as highly recurrent mutational targets and early events in the evolutionary history of FL/DLBCL, the loss of which contributes to the pathogenesis of these diseases by remodeling the epigenome of the GC.


Meet The Team

Riccardo Dalla-Favera, MD

Professor of Pathology & Cell Biology, Genetics & Development, Microbiology & Immunology

Laura Pasqualucci, MD

Professor of Pathology & Cell Biology

Katia Basso, PhD

Associate Professor of Pathology & Cell Biology

Elodie Bal, PhD

Postdoctoral Research Scientist

Bowen Cai, PhD

Associate Research Scientist

Clarissa Corinaldesi, PhD

Postdoctoral Research Scientist

Sanaz Firouzi, PhD

Postdoctoral Research Scientist

Antony Holmes, PhD

Associate Research Scientist

Rahat Jahan, PhD

Postdoctoral Research Scientist

Stefanie Meyer, PhD

Postdoctoral Research Scientist

Tongwei Mo

Sr Research Worker

Sofija Vlasevska

Sr Research Worker

Claudio Scuoppo, PhD

Instructor

Qiong Shen

Senior Staff Associate

Chuanjiang Yu, PhD

Postdoctoral Research Scientist

Selected Publications

No publications found.

See more on