Antonio Iavarone, MD

Professor of Neurology, Pathology & Cell Biology

The research program pursued by Antonio Iavarone seeks to unravel the biologic and genetic alterations driving subgroups of malignant brain tumors and exploit this information for rational therapeutic stratification. The Iavarone group identified master regulators of cancer initiation and progression in distinct sub-groups of brain tumors. They discovered the first example of oncogenic and tumor addicting gene fusions in glioblastoma (FGFR3-TACC3) and reported that FGFR3-TACC3 fusions trigger tumorigenesis through activation of oxidative phosphorylation. These fusions are among the most frequent chromosomal translocations across all types of human cancer and the FDA approved the targeting of these chromosomal translocations with FGFR inhibitors. Antonio Iavarone chaired the Pan-Glioma ATLAS-TCGA Working Group and the Neurofibromatosis 1 synodos that united international researchers to formulate guidelines for accurate diagnosis and prognosis of glioma patients. By using all the computational and experimental tools at disposal, they combine innovations in both areas to continue making transformative mechanistic discoveries and provide personalized therapeutics to increasing number of patients with deadly tumor types.


Meet The Team

Antonio Iavarone, MD

Professor of Neurology, Pathology & Cell Biology

Anna Lasorella, MD

Professor of Pediatrics, Pathology & Cell Biology

Fulvio D'Angelo, PhD

Postdoctoral Research Scientist

Qiwen Gan, PhD

Postdoctoral Research Scientist

Luciano Garofano, PhD

Postdoctoral Research Scientist

Mohammad Hasanain, PhD

Postdoctoral Research Scientist

Simona Migliozzi

Staff Associate

Michael Oh, PhD

Postdoctoral Research Scientist

Selected Publications

No publications found.

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